Structure of PDB 5yof Chain B

Receptor sequence
>5yofB (length=156) Species: 64320 (Zika virus) [Search protein sequence]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKSGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
3D structure
PDB5yof Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor
ChainB
Resolution1.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HS B H51 D129 Y130 A132 S135 G151 N152 G153 Y161 H36 D114 Y115 A117 S120 G136 N137 G138 Y146 PDBbind-CN: -logKd/Ki=5.82,IC50=1.5uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5yof, PDBe:5yof, PDBj:5yof
PDBsum5yof
PubMed29526431
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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