Structure of PDB 5yhw Chain B

Receptor sequence

>5yhwB (length=453) Species: 9823 (Sus scrofa) [Search protein sequence]

TVKVINDPIHGHIELHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHN
RFEHSLGVGYLAGCLVRELSEKQPELQISERDMLCVQIAGLCRNLGHGPF
SHMFDGRFIPLARPDVKWTHEQGSVNMFEHLVNSNGLIDVMEHYGLIPEE
DIWFIKEQITGPWPYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHH
LGIQNNFDYKRFIKFARVCEVDNKKHICTREKEVGNLYDMFHTRNCLHRR
AYQHKVGNIIDTMITDAFLKADPYIEITGSEGKKYRISTAIDDMEAFTKL
TDNIFLEILYSTDPKLDAARAILKKIECRNLYKFVGETQPGRQDKIKREN
YESLPKGVASAFIVDVINMDYGMEDKNPIDNVRFYCKSDPNKAIIITKNQ
VSQLLPERFAEQLIRVYCKKTDEKSLFAARQHFVQWCLDNDFTKPQDGDV
VAP

3D structure

PDB

5yhw Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	B	K116 I118 D137 R145	K3 I5 D24 R32
BS02	DGT	B	R333 R352 K354	R211 R230 K232
BS03	DGT	B	Q149 L150 R164 R206 H210 H215 H233 K312 Y315 R366 Y374 Q375	Q36 L37 R51 R93 H97 H102 H120 K190 Y193 R244 Y252 Q253
BS04	DGT	B	V156 V378 R451	V43 V256 R329
BS05	DGT	B	V117 N119 H125	V4 N6 H12
BS06	DGT	B	V156 F157 I325 R372 H376 K377	V43 F44 I203 R250 H254 K255

External links

PDB	RCSB:5yhw, PDBe:5yhw, PDBj:5yhw
PDBsum	5yhw
PubMed	31152619
UniProt	I3LG77

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