Structure of PDB 5yh2 Chain B

Receptor sequence
>5yh2B (length=428) Species: 9606 (Homo sapiens) [Search protein sequence]
SSKLQALFAHPLYNVPEEPPLLGAEDSLLASQEALRYYRRKVARWNRRHK
MYPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADY
SQDEKALLGACDCTQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETP
VDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVTKN
EILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGKPHLLEGSLSAFLPSLN
LAPRLSVPNPWIRSYTLAGKEEWEVNPLYCDTVKQIYPYNNSQRLLNVID
MAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEISILSP
LSQCCMIKKKTLLHLQLLAQADYRLSDVMRESLLEDQLSPVLTEPHLLAL
DRRLQTILRTVEGCIVAHGQQSVIVDGP
3D structure
PDB5yh2 Structure and evolution of the Fam20 kinases
ChainB
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B Y125 K129 K233 P279 S341 F343 S346 L347 R352 Y37 K41 K135 P181 S243 F245 S248 L249 R254
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0009617 response to bacterium
GO:0031214 biomineral tissue development
GO:0044691 tooth eruption
GO:0055074 calcium ion homeostasis
GO:0070166 enamel mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5yh2, PDBe:5yh2, PDBj:5yh2
PDBsum5yh2
PubMed29572475
UniProtQ96MK3|FA20A_HUMAN Pseudokinase FAM20A (Gene Name=FAM20A)

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