Structure of PDB 5yg7 Chain B

Receptor sequence
>5yg7B (length=322) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
AMIVKEVYETAEKIKSMEIRGAGRIARAAAQALMIQAEKSKAKEPEELWN
ELKVASKILYNTRPTAVSLPNALRYVMHRVKAAYLGGADLETLRFTAINS
AKEFIYNSEKAIERIGEIGAKRIEDGDIIMTHCHSKAAISVMKKAFEQGK
NIKVIVTETRPKWQGKITAKELASYGIPVIYIVDSAARHYMKMTDKVVMG
ANSITANGAVINKIGTSLIALTAKEHRVWVMIAAETYKFHPATMLGQLVE
IEMRDPTEVIPEEELRTWPKNIEVWNPAFDVTPPEYIDVIITERGIIPPY
AAIDILKEEFGWALKYKEPWED
3D structure
PDB5yg7 A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.3.1.29: ribose-1,5-bisphosphate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RI2 B R22 G23 A24 G25 R65 S137 K138 A139 N204 N214 K215 K240 R20 G21 A22 G23 R63 S135 K136 A137 N202 N212 K213 K238 MOAD: Kd=10uM
BS02 G B E264 L267 R268 I274 E262 L265 R266 I272
BS03 G B T207 N209 L250 V251 T205 N207 L248 V249
BS04 G B R124 R229 W231 R122 R227 W229
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0043917 ribose 1,5-bisphosphate isomerase activity
GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity
Biological Process
GO:0019323 pentose catabolic process
GO:0019509 L-methionine salvage from methylthioadenosine
GO:0044237 cellular metabolic process
GO:0044249 cellular biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5yg7, PDBe:5yg7, PDBj:5yg7
PDBsum5yg7
PubMed29382938
UniProtO57947|R15PI_PYRHO Ribose 1,5-bisphosphate isomerase (Gene Name=PH0208)

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