Structure of PDB 5yf0 Chain B

Receptor sequence
>5yf0B (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
ERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLH
LDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEDGNGKIMPASTFDMDKL
KSTLKQFVRDWSETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPG
AGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIH
QFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDC
IATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIE
LSYEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKP
Q
3D structure
PDB5yf0 Molecular basis for histidine N1 position-specific methylation by CARNMT1.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.22: carnosine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B R167 Y181 G208 E229 W230 D295 F296 C312 F313 F314 T317 Y324 Y386 R109 Y123 G150 E171 W172 D237 F238 C254 F255 F256 T259 Y266 Y328
BS02 CA B S246 D279 S188 D221
Gene Ontology
Molecular Function
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5yf0, PDBe:5yf0, PDBj:5yf0
PDBsum5yf0
PubMed29463897
UniProtQ8N4J0|CARME_HUMAN Carnosine N-methyltransferase (Gene Name=CARNMT1)

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