Structure of PDB 5yeg Chain B

Receptor sequence

>5yegB (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]

KPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHM
RTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIAR
KSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSH

3D structure

PDB

5yeg Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites

Chain

Resolution

2.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	E362 S364 Y392 R457 K487	E14 S16 Y44 R109 K139
BS02	dna	B	K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 F416 Q418 T421 H425 I446 A447 R448 D451 H455 Q459 R479	K17 R20 H21 S24 R29 Y38 R41 K45 R48 H49 T52 F68 Q70 T73 H77 I98 A99 R100 D103 H107 Q111 R131
BS03	ZN	B	C353 C356 H369 H373	C5 C8 H21 H25
BS04	ZN	B	C409 C412 H425 H430	C61 C64 H77 H82
BS05	ZN	B	C439 C442 H455 H460	C91 C94 H107 H112
BS06	ZN	B	C469 C472 H485 H489	C121 C124 H137 H141
BS07	ZN	B	C381 C384 H397 H401	C33 C36 H49 H53

External links

PDB	RCSB:5yeg, PDBe:5yeg, PDBj:5yeg
PDBsum	5yeg
PubMed	29076501
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)