Structure of PDB 5ye4 Chain B

Receptor sequence

>5ye4B (length=211) Species: 10090 (Mus musculus) [Search protein sequence]

DIQMTQSPSSLSASLGDKVTITCRASQDINNYIAWFQHKPGKGPRLLIYY
TSTLQPGIPSRFSGSGSGRDYSFSIRNLEPEDIATYYCLQYDNLRTFGGG
TKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKID
GSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS
TSPIVKSFNRN

3D structure

PDB

5ye4 JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states.

Chain

Resolution

1.799 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Y32 Y49 Q55 L89 Y91 D92 R95	Y32 Y49 Q55 L89 Y91 D92 R95
BS02	ZN	B	E184 H188	E184 H188

External links

PDB	RCSB:5ye4, PDBe:5ye4, PDBj:5ye4
PDBsum	5ye4
PubMed	30080437

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