Structure of PDB 5yd2 Chain B

Receptor sequence
>5yd2B (length=346) Species: 885315 (Entamoeba histolytica HM-3:IMSS) [Search protein sequence]
HNFGAMAKEVIEATAKAVNNFWEGLSILEISHRSKEWINVMNETKALMKE
VMDIPEGYEILFFGGGASLQFLMVAMNLLNKKACYLDTGVWASKAIKEAE
NIGEVKIIGTSKDKNYTYIPEYQIPSDYDYFHITTNNTIYGTEIRKDIES
PIPLVADMSSDILSKPIDISKYSLIYAGAQKNCGAAGVTIVIIKKEILGK
VQRKIPIILDYQVHILNNSMYNTPPVISIFTVNQTLKYIKKIGGLKKIQE
LNEEKARLLYAEIDRNKIFRGTVRKKDRSIMNVCFVMEEQYKQLENEFSE
YALQKGIIGIKGHRSVGGFRASIYNAVTIESVQALIKCMHDFEQLH
3D structure
PDB5yd2 N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B N228 T229 N222 T223
BS02 PLP B G72 A73 S74 W97 T144 D163 S165 K187 G66 A67 S68 W91 T138 D157 S159 K181
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5yd2, PDBe:5yd2, PDBj:5yd2
PDBsum5yd2
PubMed30959130
UniProtM7XC02

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