Structure of PDB 5y7z Chain B

Receptor sequence
>5y7zB (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLS
NEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLT
ELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRD
LKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT
PMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVN
GKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVN
PKSPITELLEQN
3D structure
PDB5y7z Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.
ChainB
Resolution2.804 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D173 K175 N178 D191 T223
Catalytic site (residue number reindexed from 1) D150 K152 N155 D168 T200
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IRE B K69 E124 L125 C126 G128 E132 L180 C190 D191 K46 E101 L102 C103 G105 E109 L157 C167 D168
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5y7z, PDBe:5y7z, PDBj:5y7z
PDBsum5y7z
PubMed30214852
UniProtO14976|GAK_HUMAN Cyclin-G-associated kinase (Gene Name=GAK)

[Back to BioLiP]