Structure of PDB 5y4q Chain B

Receptor sequence
>5y4qB (length=279) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWG
TVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLRE
VLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFV
RQTPDNTYDVVIIDTTASKLAFYKDVLRILKPDGICCNQGESIWLDLELI
EKMSRFIRETGFASVQYALMHVPTYSIGTLVCSKKAGVDVTKPLRPVEDM
PFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB5y4q Discovering a hidden allosteric binding site by combining molecular simulations and X-ray crystallography
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M B Q40 L59 Q64 G95 D98 D118 I119 G150 D168 T169 A176 L179 Q36 L55 Q60 G91 D94 D114 I115 G146 D164 T165 A167 L170
BS02 8OF B E14 W53 I63 Q64 D69 Y73 T236 Y237 E10 W49 I59 Q60 D65 Y69 T224 Y225
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5y4q, PDBe:5y4q, PDBj:5y4q
PDBsum5y4q
PubMed37521650
UniProtQ4DA73

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