Structure of PDB 5y4p Chain B

Receptor sequence
>5y4pB (length=278) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWG
TVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLRE
VLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFV
RQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMS
RFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMP
FAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB5y4p Discovering a hidden allosteric binding site by combining molecular simulations and X-ray crystallography
ChainB
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M B Q64 H74 G95 D98 D118 I119 D168 Q60 H70 G91 D94 D114 I115 D164
BS02 8QO B E14 M24 L26 W53 I63 D69 Y73 Y237 E10 M20 L22 W49 I59 D65 Y69 Y221
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5y4p, PDBe:5y4p, PDBj:5y4p
PDBsum5y4p
PubMed37521650
UniProtQ4DA73

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