Structure of PDB 5y2t Chain B

Receptor sequence
>5y2tB (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
SAMGSESADLRALAKHLYDSYIKSFPLTKAKARAILTGSPFVIYDMNSLM
MGEDKIKFKHITKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLN
DQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN
LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETD
MSLHPLLQEIYKD
3D structure
PDB5y2t Structures of PPAR gamma complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8LX B L255 E259 F264 H266 I281 F282 C285 Q286 S289 H323 Y327 I341 M348 F363 M364 H449 L49 E53 F58 H60 I69 F70 C73 Q74 S77 H111 Y115 I129 M136 F151 M152 H237
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y2t, PDBe:5y2t, PDBj:5y2t
PDBsum5y2t
PubMed29203903
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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