Structure of PDB 5xxz Chain B

Receptor sequence
>5xxzB (length=1310) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
LPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDVST
AKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVEAGMHVTGIVAGNSK
EAAATGERFLGIAPEAQVMFMRVFANDVMGSAESLFIKAIEDAVALGADV
INLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNERVYGSDHDDP
LATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLMTVEELEKRADLNHGK
AIYSESIKDSLGYDKSHQFAYQDVKGKIALIERDPNKTYDEMIALAKKHG
AISHEFGKAMSQLNGNGTGSVSKAPSQKGNEMNHFSNWGLTSDGYLKPDI
TAPGSQTGTAMASPQIAGASLLVKQYLEKTQPNLPKEKIADIVKNLLMSN
AQIHVNPETKTTTSPRQQGAGLLNIDGAVTSGLYVTGKDNYGSISLGNIT
DTMTFDVTVHNLSNKDKTLRYDTELLTDHVDPQKGRFTLTSRSLKTYQGG
EVTVPANGKVTVRVTMDVSQFTKELTKQMPNGYYLEGFVRFRDSQDDQLN
RVNIPFVGFKGQFENLAVAEESIYRLKSQGKTGFYFDESGPKDDIYVGKH
FTGLVTLGSETNVSTKTISDNGLHTLGTFKNADGKFILEKNAQGNPVLAI
SPNGDNNQDFAAFKGVFLRKYQGLKASVYHASDKEHKNPLWVSPESFKGD
KNFNSDIRFAKSTTLLGTAFSGKSLTGAELPDGYYHYVVSYYPDVVGAKR
QEMTFDMILDRQKPVLSQATFDPETNRFKPEPLKDRGLAGVRKDSVFYLE
RKDNKPYTVTINDSYKYVSVEDNKTFVERQADGSFILPLDKAKLGDFYYM
VEDFAGNVAIAKLGDHLPQTLGKTPIKLKLTDGNYQTKETLKDNLEMTQS
DTGLVTNQAQLAVVHRNQPQSQLTKMNQDFFISPNEDGNKDFVAFKGLEN
NVYNDLTVNVYAKDDHQKQTPIWSSQAGAGASAIESTAWYGITARGSKVM
PGDYQYVVTYRDEHGKEHQKQYTISVNDKKPMITQGRFDTINGVDHFTPD
KTKALGSSGIVREEVFYLAKKNGRKFDVTEGKDGITVSDNKVYIPKNPDG
SYTISKRDGVTLSDYYYLVEDRAGNVSFATLRDLKAVGKDKAVVNFGLDL
PVPEDKQIVNFTYLVRDADGKPIENLEYYNNSGNSLILPYGKYTVELLTY
DTNAAKLESDKIVSFTLSADNNFQQVTFKMTMLATSQITAHFDHLLPEGS
RVSLKTAQGQLIPLEQSLYVPKAYGKTVQEGTYEVVVSLPKGYRIELPNE
VHELSLRLVK
3D structure
PDB5xxz Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism.
ChainB
Resolution3.085 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D1017 Q1019 D1042 R1043 D1110 D760 Q762 D785 R786 D853
BS02 CA B S1190 N1192 D1194 N1196 D1198 S933 N935 D937 N939 D941
BS03 CA B S908 N910 D912 N914 D916 S651 N653 D655 N657 D659
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xxz, PDBe:5xxz, PDBj:5xxz
PDBsum5xxz
PubMed30049896
UniProtQ3HV58

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