Structure of PDB 5xxk Chain B

Receptor sequence
>5xxkB (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIATKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB5xxk Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.
ChainB
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F55 Y56 Q59 F38 Y39 Q42
BS02 peptide B Q18 I19 Q24 L54 F55 G58 I61 Y67 Q72 H73 F86 V93 H96 I99 Q1 I2 Q7 L37 F38 G41 I44 Y50 Q55 H56 F69 V76 H79 I82
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xxk, PDBe:5xxk, PDBj:5xxk
PDBsum5xxk
PubMed29228061
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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