Structure of PDB 5xvk Chain B

Receptor sequence
>5xvkB (length=258) Species: 10090 (Mus musculus) [Search protein sequence]
GFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGA
VKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPG
AFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVS
LPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSY
YMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLF
SLVGRKPG
3D structure
PDB5xvk Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
ChainB
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 T87 C141 D142 V143 T163 L164 C165 A169 Y8 Y17 Y22 G60 S61 T64 Y66 D82 Y83 T84 C138 D139 V140 T160 L161 C162 A166
BS02 8GC B Y24 L164 A198 S201 Y204 S213 Y242 Y21 L161 A195 S198 Y201 S210 Y239 MOAD: ic50=9uM
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:5xvk, PDBe:5xvk, PDBj:5xvk
PDBsum5xvk
PubMed28720493
UniProtO55239|NNMT_MOUSE Nicotinamide N-methyltransferase (Gene Name=Nnmt)

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