Structure of PDB 5xig Chain B

Receptor sequence
>5xigB (length=478) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence]
MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFF
DDEIKKMGVENSYFPMFVSRHKLEKFSPEVAWVTHYGDSPLPEKIAIRPT
SETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQE
GHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKK
TTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSW
GCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFTGEILGKCRELK
TMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTARV
VRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKISTFD
EVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEGAMKTLCIPF
DQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB5xig Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B R470 E472 K474 R481 T482 F485 Q555 T592 R594 R131 E133 K135 R142 T143 F146 Q216 T253 R255
BS02 87F B F415 P438 T439 E441 R470 W487 F534 H560 S588 W589 F76 P99 T100 E102 R131 W148 F195 H221 S249 W250 MOAD: ic50=350nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xig, PDBe:5xig, PDBj:5xig
PDBsum5xig
PubMed28867614
UniProtS8G8I1

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