Structure of PDB 5xhc Chain B

Receptor sequence

>5xhcB (length=424) Species: 41807 (Sus barbatus)

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTSQYRALTVPELTQQMFDSKNMMAACD
PRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVC
DIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMD
EMEFTEAESNMNDLVSEYQQYQDA

3D structure

• PDB: 5xhc Synthesis, biological evaluation and X-ray structure of anti-microtubule agents
• Chain: B
• Resolution: 2.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDP	B	G10 Q11 C12 Q15 S138 G141 G142 T143 G144 D177 E181 N204 Y222 N226	G10 Q11 C12 Q15 S138 G141 G142 T143 G144 D177 E181 N204 Y222 N226
BS02	87U	B	Q134 N165 F167 E198 Y200 M233 V236 T237 C239 L240 L250 L253 A314 A352 I368	Q134 N165 F167 E198 Y200 M233 V236 T237 C239 L240 L250 L253 A310 A348 I364

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:5xhc, PDBe:5xhc, PDBj:5xhc
• PDBsum: 5xhc
• UniProt: A0A0R4I995