Structure of PDB 5xfr Chain B

Receptor sequence

>5xfrB (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]

KFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQ
TCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDCKWLCRQCVFATTT
KRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPG
DWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLK
RLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELAD
TPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVA

3D structure

PDB

5xfr Polycomb-like proteins link the PRC2 complex to CpG islands

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	W56 Y62 F80 D82	W12 Y18 F36 D38
BS02	dna	B	K284 Y285 I337 K338 K339	K224 Y225 I277 K278 K279
BS03	dna	B	K338 K339 K340 K341	K278 K279 K280 K281
BS04	ZN	B	C122 C125 C154	C69 C72 C94
BS05	ZN	B	C105 C108 H130 C133	C52 C55 H77 C80
BS06	ZN	B	C204 C206 H227 C230	C144 C146 H167 C170
BS07	ZN	B	C219 C222 C249 C252	C159 C162 C189 C192

External links

PDB	RCSB:5xfr, PDBe:5xfr, PDBj:5xfr
PDBsum	5xfr
PubMed	28869966
UniProt	Q9Y483\|MTF2_HUMAN Metal-response element-binding transcription factor 2 (Gene Name=MTF2)

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