Structure of PDB 5xfp Chain B

Receptor sequence

>5xfpB (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]

RLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDIS
PAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPSWV
CRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQ
QSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECC
VCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENW
DSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARM
PPPVE

3D structure

PDB

5xfp Polycomb-like proteins link the PRC2 complex to CpG islands

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K323 K324 R325 K326	K288 K289 R290 K291	PDBbind-CN: Kd=1.2uM
BS02	dna	B	K268 K269 Y270 I322 K323 K324	K233 K234 Y235 I287 K288 K289	PDBbind-CN: Kd=1.2uM
BS03	ZN	B	C107 C110 C136 C139	C78 C81 C101 C104
BS04	ZN	B	C90 C93 H115 C118	C61 C64 H86 C89
BS05	ZN	B	C189 C191 H212 C215	C154 C156 H177 C180
BS06	ZN	B	C204 C207 C237	C169 C172 C202

External links

PDB	RCSB:5xfp, PDBe:5xfp, PDBj:5xfp
PDBsum	5xfp
PubMed	28869966
UniProt	O43189\|PHF1_HUMAN PHD finger protein 1 (Gene Name=PHF1)

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