Structure of PDB 5x94 Chain B

Receptor sequence
>5x94B (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTTR
3D structure
PDB5x94 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R32 S36 T42 T52 H53 K55 G67 L88 K89 E90 R30 S34 T40 T50 H51 K53 G65 L86 K87 E88
BS02 peptide B R138 S140 Q141 S142 V148 H169 V181 G183 G184 M202 V203 E204 T205 R136 S138 Q139 S140 V146 H156 V168 G170 G171 M189 V190 E191 T192
External links
PDB RCSB:5x94, PDBe:5x94, PDBj:5x94
PDBsum5x94
PubMed28930683
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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