Structure of PDB 5x8i Chain B

Receptor sequence
>5x8iB (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAAR
SEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE
NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEA
YNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILAL
GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQ
KTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLI
QKMLEYDPAKRITLREALKHPFFDLLK
3D structure
PDB5x8i Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers
ChainB
Resolution1.902 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D288 K290 N293 D325 T342
Catalytic site (residue number reindexed from 1) D134 K136 N139 D171 T188
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SQZ B L167 G168 F172 V175 A189 K191 F241 L244 N293 L295 D325 L13 G14 F18 V21 A35 K37 F87 L90 N139 L141 D171 MOAD: ic50=2nM
PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
BindingDB: IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5x8i, PDBe:5x8i, PDBj:5x8i
PDBsum5x8i
PubMed28692292
UniProtP49759|CLK1_HUMAN Dual specificity protein kinase CLK1 (Gene Name=CLK1)

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