Structure of PDB 5x8a Chain B

Receptor sequence
>5x8aB (length=189) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLL
LTQELSPEAEYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQG
YGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRGLEFFRRVR
EGYLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP
3D structure
PDB5x8a Structural and functional roles of dynamically correlated residues in thymidylate kinase.
ChainB
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B G13 S14 G15 K16 T17 T18 R140 L180 E182 G12 S13 G14 K15 T16 T17 R139 L171 E173
BS02 MG B F65 S96 Q100 F64 S95 Q99
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:5x8a, PDBe:5x8a, PDBj:5x8a
PDBsum5x8a
PubMed29652261
UniProtQ5SHX3|KTHY_THET8 Thymidylate kinase (Gene Name=tmk)

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