Structure of PDB 5x6r Chain B

Receptor sequence

>5x6rB (length=361) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

ESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLLKSINLAISARGI
DALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYGLHGEAINSINR
SVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFHTEKYDFVIGCD
GAYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAIAP
DHLHIWPRHKFMLIALANSDGSFTSTFFGSKDQISDLITSKSRVREFLIE
NFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAAHA
MVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSITE
LAKRNYKEMSH

3D structure

PDB

5x6r Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

Chain

Resolution

1.911 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.9: kynurenine 3-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G9 V13 D32 F33 L52 A53 R109 K132 L133 D168 G169 Y195 D314 P321 Q325 G326 M327 N328	G7 V11 D30 F31 L43 A44 R100 K123 L124 D150 G151 Y177 D296 P303 Q307 G308 M309 N310
BS02	7ZR	B	A53 I104 L221 I232 L234 F246 F322 Y323 Q325	A44 I95 L203 I214 L216 F228 F304 Y305 Q307

Gene Ontology

	Molecular Function
GO:0071949	FAD binding

View graph for
Molecular Function

External links

PDB	RCSB:5x6r, PDBe:5x6r, PDBj:5x6r
PDBsum	5x6r
PubMed	29429898
UniProt	P38169\|KMO_YEAST Kynurenine 3-monooxygenase (Gene Name=BNA4)

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