Structure of PDB 5x4z Chain B

Receptor sequence
>5x4zB (length=1070) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence]
ITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIIRFG
KIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSPVYLDMEKKVHIGKVPI
MLRSKFCSLRTLDEVDLYKMKECPYDMGGYFVINGSEKVLIAQESAANIV
QVFKKAAPSPISHVAEIRSALEKGSRLISTMQIKLYGREDKGRTIKATLP
YVKQDIPIVIVFRALGVVPDGEILQHICYDENDWQMLEMLKPCIEEGFVI
QDKEVALDFIGEKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNR
LLLCALERKDQDDRDHFGKLDLAGPLLANLFRILFRKLTREIYRYMQRCI
ELAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSH
LRRTNTPIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGISIGSP
SEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSMLVSTM
RDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDESKDNEL
RITKEHIRKIVYGWSSLVTSGVIEYVDGEEEETIMIAMTPEDLDTAKRIK
PTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNY
NVRMDTMANILYYPQKPLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQ
EDSMIMNQSSIDRGLFRSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRL
KHGTYEKLDEDGLIAPGVRVSGDDIIIGKTTPDASTPLRSTENGIVDQVL
LTTNQEGLKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSA
EGIVPDLIINPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVD
AVSNLLRDNGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKI
HARARGPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKELMEA
SDAFRVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLF
QELMAMNIAPRLYTERSGVS
3D structure
PDB5x4z Crystal structure of RNA polymerase II from Komagataella pastoris
ChainB
Resolution7.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1163 C1166 C1185 C1009 C1012 C1031
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x4z, PDBe:5x4z, PDBj:5x4z
PDBsum5x4z
PubMed28412353
UniProtC4QZQ7

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