Structure of PDB 5x3s Chain B

Receptor sequence
>5x3sB (length=223) Species: 10090 (Mus musculus) [Search protein sequence]
ECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSS
3D structure
PDB5x3s Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
ChainB
Resolution2.899 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B A495 N496 A125 N126
BS02 peptide B W414 D416 Y485 H489 L490 L491 R516 H538 K540 W44 D46 Y115 H119 L120 L121 R146 H168 K170
External links
PDB RCSB:5x3s, PDBe:5x3s, PDBj:5x3s
PDBsum5x3s
PubMed29191835
UniProtQ07832|PLK1_MOUSE Serine/threonine-protein kinase PLK1 (Gene Name=Plk1)

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