Structure of PDB 5wyz Chain B

Receptor sequence
>5wyzB (length=745) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNE
SFQGLQNLTKINLNHNPNVNGLNITDGAFLNLKNLRELLLEDNQLPQIPS
GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNI
EDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDF
KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYL
NLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL
DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ
LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTFDPHS
NFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSAN
SNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNS
HYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVF
SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS
LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLR
TLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKTKLSMLELHGNP
FECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB5wyz Small-molecule inhibition of TLR8 through stabilization of its resting state
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7VF B F261 Y348 K350 G351 F405 F219 Y306 K308 G309 F363 MOAD: Kd=21nM
PDBbind-CN: -logKd/Ki=7.68,Kd=21nM
BS02 7VF B F494 F495 A518 Q519 Y567 F429 F430 A453 Q454 Y502 MOAD: Kd=21nM
PDBbind-CN: -logKd/Ki=7.68,Kd=21nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wyz, PDBe:5wyz, PDBj:5wyz
PDBsum5wyz
PubMed29155428
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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