Structure of PDB 5wvd Chain B

Receptor sequence
>5wvdB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSR
VFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQASR
VVRDVAAALDFLHTKGIAHRDLKPENILCESPVSPVKICDFDLGSGMEYM
APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPDLISKLLVRDAKQR
LSAAQVLQHPWV
3D structure
PDB5wvd A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D170 K172 N175 D191
Catalytic site (residue number reindexed from 1) D121 K123 N126 D140
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7UX B L55 V63 L108 L127 G129 L177 D191 F192 L15 V23 L68 L87 G89 L128 D140 F141 PDBbind-CN: -logKd/Ki=7.68,IC50=21nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wvd, PDBe:5wvd, PDBj:5wvd
PDBsum5wvd
PubMed29497019
UniProtQ9BUB5|MKNK1_HUMAN MAP kinase-interacting serine/threonine-protein kinase 1 (Gene Name=MKNK1)

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