Structure of PDB 5wu4 Chain B

Receptor sequence
>5wu4B (length=483) Species: 9606 (Homo sapiens) [Search protein sequence]
DSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLRSLVVALMQEVFTEF
FPGCVVHPFGSSINSFDVHGCDLDLFLDLETPKEEKAEGAAMLELVGSIL
RGCVPGVYRVQTVPSARRPVVKFAHRPSGLHGDVSLSNRLALHNSRFLSL
CSELDGRVRPLVYTLRAWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPP
VLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQF
FSAVSSWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLS
HNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPS
SPSSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQSASWRCALWHR
VWQGRRRARRRLQQQTKGWLATEAQVTQELKTEPLLSFVASVSPADRMLT
VTPLQDPQGLFPDLHHFLQVFLPQAIRHLKLEH
3D structure
PDB5wu4 Crystal structures of U6 snRNA-specific terminal uridylyltransferase
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B S205 D216 D218 A389 N392 Y432 H549 S61 D72 D74 A141 N144 Y184 H301
BS02 MG B S205 D216 D218 S61 D72 D74
External links
PDB RCSB:5wu4, PDBe:5wu4, PDBj:5wu4
PDBsum5wu4
PubMed28589955
UniProtQ9H6E5|STPAP_HUMAN Speckle targeted PIP5K1A-regulated poly(A) polymerase (Gene Name=TUT1)

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