Structure of PDB 5wgq Chain B

Receptor sequence
>5wgqB (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5wgq A "cross-stitched" peptide with improved helicity and proteolytic stability.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 N359 K362 L372 H373 V376 E380 E542 M543 I50 N51 K54 L64 H65 V68 E72 E223 M224
BS02 EST B M343 E353 L387 H524 L525 M35 E45 L79 H205 L206 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5wgq, PDBe:5wgq, PDBj:5wgq
PDBsum5wgq
PubMed29725689
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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