Structure of PDB 5wgd Chain B

Receptor sequence
>5wgdB (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSSEASMMGLLTNLADRELVHMINWAKRV
PGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQ
GKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDHIH
RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLY
SMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5wgd A "cross-stitched" peptide with improved helicity and proteolytic stability.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 N359 L372 M543 I44 N45 L58 M217
BS02 EST B E353 F404 H524 L525 E39 F90 H198 L199 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5wgd, PDBe:5wgd, PDBj:5wgd
PDBsum5wgd
PubMed29725689
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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