Structure of PDB 5wej Chain B

Receptor sequence
>5wejB (length=162) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
TLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQAG
EFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGA
IASMRIQGRLVHGQSGMLLTGLGTIPGDCGAPYVHKRGNDWVVCGVHAAA
TKSGNTVVCAVQ
3D structure
PDB5wej Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V45 B H30 Q110 T134 C139 H157 A158 A159 A160 H27 Q107 T124 C129 H147 A148 A149 A150
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5wej, PDBe:5wej, PDBj:5wej
PDBsum5wej
PubMed29227928
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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