Structure of PDB 5we8 Chain B

Receptor sequence
>5we8B (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
LETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRK
LTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGCIVLVTELMTSGT
LKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT
GPTGSVKIGDLGLATLKRADFAKSVIGTPEFMAPEMYAAAYDESVDVYAF
GMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEG
CIRQNKDERYSIKDLLNHAFFQ
3D structure
PDB5we8 Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
ChainB
Resolution2.006 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D349 K351 D353 N354 D368 K375 T386
Catalytic site (residue number reindexed from 1) D141 K143 D145 N146 D160 K167 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B N354 D368 N146 D160
BS02 ANP B K233 L303 M304 K351 K27 L95 M96 K143
BS03 A7Y B F265 E268 M271 L272 F283 L299 I345 D368 L369 G370 A372 L374 F59 E62 M65 L66 F77 L91 I137 D160 L161 G162 A164 L166 BindingDB: IC50=750nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5we8, PDBe:5we8, PDBj:5we8
PDBsum5we8
PubMed28771350
UniProtQ9H4A3|WNK1_HUMAN Serine/threonine-protein kinase WNK1 (Gene Name=WNK1)

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