Structure of PDB 5wdy Chain B

Receptor sequence
>5wdyB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQLT
KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGT
LKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT
GPTGSVKIGDLGLATLKRTPEFMAPEMYAAAYDESVDVYAFGMCMLEMAT
SEYPYSECQNAAQIYRRVTSGSFDKVAIPEVKEIIEGCIRQNKDERYSIK
DLLNHAFFQ
3D structure
PDB5wdy Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
ChainB
Resolution2.458 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D349 K351 D353 N354 D368 K375 T386
Catalytic site (residue number reindexed from 1) D141 K143 D145 N146 D160 K167 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B N354 D368 N146 D160
BS02 ANP B G230 V235 L303 M304 D368 G25 V30 L95 M96 D160
BS03 A6S B F265 E268 A269 L272 V281 F283 L299 T301 D368 L369 F57 E60 A61 L64 V73 F75 L91 T93 D160 L161 BindingDB: IC50=39nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wdy, PDBe:5wdy, PDBj:5wdy
PDBsum5wdy
PubMed28771350
UniProtQ9H4A3|WNK1_HUMAN Serine/threonine-protein kinase WNK1 (Gene Name=WNK1)

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