Structure of PDB 5w9c Chain B

Receptor sequence
>5w9cB (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKSKNVVPSYDLLLEMLD
3D structure
PDB5w9c Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
ChainB
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT B A350 D351 E353 W383 L387 L525 V533 A41 D42 E44 W74 L78 L214 V222 BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
External links
PDB RCSB:5w9c, PDBe:5w9c, PDBj:5w9c
PDBsum5w9c
PubMed29739819
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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