Structure of PDB 5w7e Chain B

Receptor sequence
>5w7eB (length=526) Species: 10090 (Mus musculus) [Search protein sequence]
SHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYF
LVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQCHLYPLPQEAWESAL
EKARQVLRRICSLPFLTKICQKIELSIKKAVPFKDVDSDKHSVFPTLRGY
HWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFC
EGSQPRGIILLGDAAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWP
QLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKN
FIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQT
LTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFS
FLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLF
YVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQL
QWPHVLGKENPFNSQIEEVFGDQGGH
3D structure
PDB5w7e Crystal structure of the mammalian lipopolysaccharide detoxifier.
ChainB
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.77: acyloxyacyl hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D183 D185 D187 H189 D204 D207 D135 D137 D139 H141 D156 D159
BS02 CA B D185 D187 D204 N206 D209 V212 D137 D139 D156 N158 D161 V164
BS03 CA B D222 D226 N228 N230 I232 E244 D174 D178 N180 N182 I184 E196
BS04 FAW B D261 A262 N372 F504 F528 H529 P530 D213 A214 N324 F456 F480 H481 P482
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
GO:0050528 acyloxyacyl hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0008653 lipopolysaccharide metabolic process
GO:0009104 lipopolysaccharide catabolic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w7e, PDBe:5w7e, PDBj:5w7e
PDBsum5w7e
PubMed29343645
UniProtO35298|AOAH_MOUSE Acyloxyacyl hydrolase (Gene Name=Aoah)

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