Structure of PDB 5w6o Chain B

Receptor sequence
>5w6oB (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
DEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSL
PDTTATLGDEPRKVLLRLYGEAMVLESVMFAILAERSLGPKLYGIFPQGR
LEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTME
KYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCH
NDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDY
SYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEE
MLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRK
LGV
3D structure
PDB5w6o Identification of a Unique Inhibitor-Binding Site on Choline Kinase alpha.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9X1 B Y148 M177 E180 F200 P201 Y256 Y333 F341 L419 W420 Y69 M73 E76 F96 P97 Y152 Y229 F237 L315 W316 MOAD: ic50=520nM
PDBbind-CN: -logKd/Ki=6.28,IC50=520nM
External links
PDB RCSB:5w6o, PDBe:5w6o, PDBj:5w6o
PDBsum5w6o
PubMed29389115
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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