Structure of PDB 5w3s Chain B

Receptor sequence
>5w3sB (length=485) Species: 9483 (Callithrix jacchus) [Search protein sequence]
LLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGL
SNQMVVAFKEENTVAFKHLFLKGYIDRMDDTYAVYTQSDVYDQIIFAVNQ
YLQLYQVSVGNHAYENSAMAICQHFYKRGNIYPGNDTFDIDPEIETDCFF
VEPDEPFHIENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDF
TLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHNMMIFDAF
VILTCLVSLILCIRSVISGLQLQQEFVNFFLLHYKKDVSVSDQMEFVNGW
YIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRY
LGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHNKF
RSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIY
MILSLFIALITDTYETIKHYQQDGFPETELRTFIS
3D structure
PDB5w3s Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
ChainB
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 B Y472 W475 I480 Y483 Y431 W434 I439 Y442
BS02 Y01 B A420 Y423 S448 A379 Y382 S407
BS03 Y01 B I67 W385 V388 Y391 I35 W344 V347 Y350
Gene Ontology
Molecular Function
GO:0005253 monoatomic anion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0008289 lipid binding
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0042802 identical protein binding
GO:0072345 NAADP-sensitive calcium-release channel activity
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:0097682 intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
Biological Process
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0051289 protein homotetramerization
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
Cellular Component
GO:0000421 autophagosome membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0042995 cell projection
GO:0060171 stereocilium membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w3s, PDBe:5w3s, PDBj:5w3s
PDBsum5w3s
PubMed29019979
UniProtF6RG56|MCLN3_CALJA Mucolipin-3 (Gene Name=MCOLN3)

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