Structure of PDB 5w2m Chain B

Receptor sequence
>5w2mB (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
NPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR
NQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAE
FLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC
WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
3D structure
PDB5w2m Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA.
ChainB
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y333 K337 F351 K352 P353 K355 G356 L357 K358 Y359 Y144 K148 F162 K163 P164 K166 G167 L168 K169 Y170 PDBbind-CN: Kd=6.36uM
BS02 ZN B H247 H249 H58 H60
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5w2m, PDBe:5w2m, PDBj:5w2m
PDBsum5w2m
PubMed29191651
UniProtQ8IUX4|ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (Gene Name=APOBEC3F)

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