Structure of PDB 5w0n Chain B

Receptor sequence

>5w0nB (length=372) Species: 9606 (Homo sapiens)

LEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQD
FPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQ
LWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNH
NLGAGLSRKMTNFIMKAFINGRRVFGIPVKGYPSKMEYFFDPDVLTEGEL
APNDRCCRICGKIGHFMKDCPM

3D structure

• PDB: 5w0n Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
• Chain: B
• Resolution: 2.497 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.52: RNA uridylyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	D1058 D1060	D72 D74
BS02	2KH	B	F1045 G1046 S1047 S1057 D1058 D1060 N1130 K1152 S1170 Y1171 L1288	F59 G60 S61 S71 D72 D74 N144 K166 S184 Y185 L302
BS03	UPU	B	F1045 D1060 I1099 T1101 A1102 V1104 I1106 N1124 S1164 I1353 H1355	F59 D74 I113 T115 A116 V118 I120 N138 S178 I363 H365
BS04	ZN	B	C1347 C1350 H1355 C1360	C357 C360 H365 C370

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

External links

• PDB: RCSB:5w0n, PDBe:5w0n, PDBj:5w0n
• PDBsum: 5w0n
• PubMed: 28671666
• UniProt: Q5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)