Structure of PDB 5vvm Chain B

Receptor sequence

>5vvmB (length=314) Species: 9606 (Homo sapiens)

SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDD
TDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNERSVSV
PNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPD
KGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRA
SDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEEDVPVGTIILTVTAT
DADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREILTALAKDNPG
DVASNRRENSVQVV

3D structure

• PDB: 5vvm Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
• Chain: B
• Resolution: 3.54 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	E2162 N2224 E2226 D2265	E16 N78 E80 D114
BS02	CA	B	E2162 E2226 D2262 V2263 D2265 D2301	E16 E80 D111 V112 D114 D150
BS03	CA	B	N2264 N2266 D2299 D2301 N2305 D2353	N113 N115 D148 D150 N154 D202
BS04	CA	B	E2284 D2338 E2340 D2374	E133 D187 E189 D223
BS05	CA	B	E2284 E2340 D2371 I2372 D2374 D2407	E133 E189 D220 I221 D223 D253
BS06	CA	B	N2373 N2375 D2405 D2407 F2411 D2456	N222 N224 D251 D253 F257 D297

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5vvm, PDBe:5vvm, PDBj:5vvm
• PDBsum: 5vvm
• PubMed: 30033219
• UniProt: Q9H251|CAD23_HUMAN Cadherin-23 (Gene Name=CDH23)