Structure of PDB 5vsm Chain B

Receptor sequence
>5vsmB (length=253) Species: 10090 (Mus musculus) [Search protein sequence]
VNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINFSG
GEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEYLD
ILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINSVI
NRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNE
EFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTPSKSILDVGV
EEA
3D structure
PDB5vsm Structural studies of viperin, an antiviral radical SAM enzyme.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C84 C88 C91
Catalytic site (residue number reindexed from 1) C9 C13 C16
Enzyme Commision number 4.2.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 B C84 Y86 C88 C91 G126 N158 R194 C9 Y11 C13 C16 G51 N83 R119
BS02 MET B S124 G125 G126 V156 S157 S180 S49 G50 G51 V81 S82 S105
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vsm, PDBe:5vsm, PDBj:5vsm
PDBsum5vsm
PubMed28607080
UniProtQ8CBB9|RSAD2_MOUSE S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (Gene Name=Rsad2)

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