Structure of PDB 5vsl Chain B

Receptor sequence
>5vslB (length=257) Species: 10090 (Mus musculus) [Search protein sequence]
VSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINF
SGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEY
LDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINS
VINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLIS
NEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTPSKSILDV
GVEEAIK
3D structure
PDB5vsl Structural studies of viperin, an antiviral radical SAM enzyme.
ChainB
Resolution1.972 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C84 C88 C91
Catalytic site (residue number reindexed from 1) C11 C15 C18
Enzyme Commision number 4.2.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 B C84 Y86 C88 C91 G126 N158 R194 C11 Y13 C15 C18 G53 N85 R121
BS02 SAH B F90 F92 S124 G125 G126 E127 V156 S157 N158 S180 R194 N222 V224 L252 F17 F19 S51 G52 G53 E54 V83 S84 N85 S107 R121 N149 V151 L179
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vsl, PDBe:5vsl, PDBj:5vsl
PDBsum5vsl
PubMed28607080
UniProtQ8CBB9|RSAD2_MOUSE S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (Gene Name=Rsad2)

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