Structure of PDB 5vrb Chain B

Receptor sequence

>5vrbB (length=646) Species: 521006 (Neisseria gonorrhoeae NCCP11945)

SQLANVIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKF
YNRDRFVLSNGHASMLLYSLLHLTGYNLSIEDLKNFRQLHSKTPGHPEYG
YTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNIVDHYTYVFMG
DGCLMEGVSHEACSLAGTLGLGKLIVLYDDNNISIDGKVDGWFTENIPQR
FESYGWHVVPNVNGHDTAAIQTAIEAARAETGKPSIICCKTLIGKGSANK
EGSHKTHGAPLGADEIEATRKHLGWAYPAFEIPQEIYDAWNAKEKGAKLE
AGWNELFAQYQAKYPAEAAEFVRRMDKKLPENFDEYVQTALKEVCAKQNS
IEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGNYIHYGVREFGM
GAIMNGLVLHGGVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSI
GLGEDGPTHQPIEQTATLRLIPNMDVWRPCDTAESLVAWAEAAKAEDHPS
CLIFSRQNFQARSEQQLNDIKRGAYVISEAQGNAQAVIIATGSEVGLAVE
AQKVLAGQGIAVRVVSMPSTSVFDRQDAAYQAAVLPEGLPRIAVEAGHTN
GWYKYVGLNGAVVGINRFGESAPADLLFKAFGFTVDNVVDTVKSVL

3D structure

• PDB: 5vrb Crystal structure of a transketolase from Neisseria gonorrhoeae
• Chain: B
• Resolution: 1.85 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H23 I244 H258 E408 Y437 H470
• Catalytic site (residue number reindexed from 1): H22 I243 H257 E397 Y426 H459
• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	D152 N182 I184	D151 N181 I183
BS02	CA	B	G151 G153 C154	G150 G152 C153

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5vrb, PDBe:5vrb, PDBj:5vrb
• PDBsum: 5vrb
• UniProt: B4RKU9