Structure of PDB 5vq2 Chain B

Receptor sequence
>5vq2B (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDEDSYRKQVVIDGETCL
LDILDTDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMV
LVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVRE
IRKHKE
3D structure
PDB5vq2 Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
ChainB
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G14 V15 G16 K17 S18 A19 F29 D31 N104 K105 D107 L108 S133 A134
BS02 MG B S17 D57 S18 D55
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5vq2, PDBe:5vq2, PDBj:5vq2
PDBsum5vq2
PubMed29199977
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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