Structure of PDB 5vpy Chain B

Receptor sequence
>5vpyB (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
HMTEYKLVVVGAAGVGKSALTIQLIQNHFVDEYDDSYRKQVVIDGETCLL
DILDTDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVL
VGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI
RKHKEK
3D structure
PDB5vpy Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S17 D57 S18 D54
BS02 9GM B G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G14 G16 K17 S18 A19 F29 D31 N103 K104 D106 L107 S132 A133
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5vpy, PDBe:5vpy, PDBj:5vpy
PDBsum5vpy
PubMed29199977
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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