Structure of PDB 5vom Chain B

Receptor sequence
>5vomB (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
NANPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5vom Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains.
ChainB
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9GY B W81 P82 L92 Y139 N140 I146 W40 P41 L51 Y98 N99 I105 MOAD: ic50=0.79uM
BindingDB: IC50=790nM
External links
PDB RCSB:5vom, PDBe:5vom, PDBj:5vom
PDBsum5vom
PubMed28835800
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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