Structure of PDB 5vkw Chain B

Receptor sequence
>5vkwB (length=469) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
MSEYDKYSTPLSSRYASEEMSKIFSLRNRFSTWRKLWLNLAIAEKEVGLS
VITDEAIEQMKQHLEITDKEIQDAAVEEAKVRHDVMAHVHVFGETCPSAA
GIIHLGATSCFVTDNADLIFLRDAYDVLIPKLVNVIDRLSKFALEYKDLP
VLGWTHFQPAQLTTVGKRATLWLQELLWDLRNMVRARNDIGLRGVKGTTG
TQASFLSLFHGDHDKVEELDKRVVELLGFDIVYPVTGQTYSRKIDIDVLS
PLASFGATAHKFATDIRLLANLKEIEEPFEKMAYKRNPMRCERVCSLARH
LGGLFNDAVQTASVQWFERTLDDSAIRRISLPSAFLTVDILLSTMLNITS
GLVVYPKVIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQA
SAVVKQEGGDNDLIERIKSTEYFKPIWNDLDTLLDPKTFVGRAPQQTEKF
VKNDVANALKPFEKYITTE
3D structure
PDB5vkw Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans
ChainB
Resolution1.998 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H83 T155 H156 K292 E299
Catalytic site (residue number reindexed from 1) H83 T155 H156 K285 E292
Enzyme Commision number 4.3.2.2: adenylosuccinate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D54 E58 D54 E58
BS02 MG B N435 D438 N428 D431
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0044208 'de novo' AMP biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5vkw, PDBe:5vkw, PDBj:5vkw
PDBsum5vkw
PubMed
UniProtA0A1D8PT56

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