Structure of PDB 5vk4 Chain B

Receptor sequence
>5vk4B (length=330) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
DAGDQLVEKIKPFAKRTMRPEVLGDLGGFGALVEIGKKYQNPVLVSGTDG
VGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDV
PRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEK
ENVITGLSVGAGDMVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGK
TLREAVIAPTRLYVKPILAALEKFTIKGMAHITGGGITENVPRVLPKNTV
AQIDAESWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAV
RSFLSGQGETVYRLGCIRERQGNEHQTQVA
3D structure
PDB5vk4 Crystal structure of a phosphoribosylformylglycinamidine cyclo-ligase from Neisseria gonorrhoeae bound to AMPPNP and magnesium
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B V21 G41 G42 D105 G137 G138 E139 T140 V7 G27 G28 D91 G123 G124 E125 T126
BS02 MG B E139 T140 E125 T126
Gene Ontology
Molecular Function
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0046084 adenine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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External links
PDB RCSB:5vk4, PDBe:5vk4, PDBj:5vk4
PDBsum5vk4
PubMed
UniProtQ5F973|PUR5_NEIG1 Phosphoribosylformylglycinamidine cyclo-ligase (Gene Name=purM)

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