Structure of PDB 5vjn Chain B

Receptor sequence
>5vjnB (length=169) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
IASYAQELKLALHQYPNFPSEGILFEDFLPIFRNPGLFQKLIDAFKLHLE
EAFPEVKIDYIVGLESRGFLFGPTLALALGVGFVPVRKAGKLPGECFKAT
YLFEIQKNAIPAGSNVIIVDDIIATGGSAAAAGELVEQLEANLLEYNFVM
ELDFLKGRSKLNAPVFTLL
3D structure
PDB5vjn Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.
ChainB
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R69
Catalytic site (residue number reindexed from 1) R67
Enzyme Commision number 2.4.2.7: adenine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IR8 B D129 D130 I131 A133 T134 G135 S137 D120 D121 I122 A124 T125 G126 S128 MOAD: Ki=8.7uM
PDBbind-CN: -logKd/Ki=5.06,Ki=8.7uM
Gene Ontology
Molecular Function
GO:0002055 adenine binding
GO:0003999 adenine phosphoribosyltransferase activity
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006168 adenine salvage
GO:0009058 biosynthetic process
GO:0044209 AMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:5vjn, PDBe:5vjn, PDBj:5vjn
PDBsum5vjn
PubMed29178779
UniProtP49435|APT1_YEAST Adenine phosphoribosyltransferase 1 (Gene Name=APT1)

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