Structure of PDB 5vih Chain B

Receptor sequence
>5vihB (length=278) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DNHLSIVTLEEAPFVIVEDIDPLTCVRNTVPCRKFVKINNSTNEGMNVKK
CCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR
AVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRP
HDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTG
KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKR
QIDLALLQFVGDGEMEELETLWLTGICH
3D structure
PDB5vih Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5DZ B H88 T116 R121 T134 G135 G172 S173 T174 Y214 D215 H81 T109 R114 T127 G128 G165 S166 T167 Y207 D208 MOAD: Ki=32.2nM
PDBbind-CN: -logKd/Ki=7.49,Ki=32.2nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5vih, PDBe:5vih, PDBj:5vih
PDBsum5vih
PubMed28760974
UniProtQ00959|NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (Gene Name=Grin2a)

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